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Air Pollution and Allergen Synergy in Allergic Airway Disease: A Prospective Observational Study

Gautam Modi

International Journal of Medical and Biomedical Studies · 2026-05-15 · DOI: 10.32553/ijmbs.v10i3.3264

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Abstract

Background: Air pollution is a major environmental risk factor that exacerbates allergic airway diseases. Interaction between airborne pollutants and allergens may amplify immune responses, leading to increased disease severity. Objective: To evaluate the synergistic effect of air pollution and allergen exposure on the severity of allergic airway diseases. Methods: A prospective observational study was conducted on 145 patients at a tertiary care allergy clinic over one year. Clinical severity, exposure history, and pollutant levels (PM2.5, PM10) were assessed. Statistical analysis included correlation and Chi-square test. Results: Patients exposed to both high pollution and allergens showed significantly higher disease severity (p < 0.001). A positive correlation (r = 0.62) was observed between pollutant levels and symptom severity. Conclusion: Air pollution significantly enhances allergen-induced airway inflammation, emphasizing the need for integrated environmental and clinical management.

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Gautam Modi (2026). Air Pollution and Allergen Synergy in Allergic Airway Disease: A Prospective Observational Study. International Journal of Medical and Biomedical Studies. https://doi.org/10.32553/ijmbs.v10i3.3264
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